Supplementary Figure 2

By F. Takeuchi, R. McGinnis, Stephane Bourgeois, Chris P. Barnes, N. Eriksson, N. Soranzo, P. Whittaker, V. Ranganath, Vasudev Kumanduri, William M. McLaren and 5 more. 2014

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Supplementary Figure 2. (A) Forward and side scatter of splenic lymphocytes. CD8β+ cells were gated on and stained for CD28, CD122 and isotype controls. (B) Forward and side scatter for the IEL and MLN. (C) Sorted CD8 cells were cultured without stimulation or with CD3/CD28 for 3 days and stained for CD8β, CD44 and CD62L antibodies. CFSE staining was analyzed in the CD44low/CD62Lhigh (naive) and CD44high/CD62Llow (activated) populations. SSC C D 28 SSC Is ot yp eC D 28

Subfields: Computational Theory and Mathematics, Numerical Analysis

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• Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine (2016, background): “Genetic polymorphisms in CYP2C19, CYP1A2, 2B6*6, and CYP3A5*3 were found to be associated with the varied degree of drug–drug interactions for clopidogrel, due to its highlycomplex pharmacokinetics and variable drug response as compare to other anti-platelet drugs [172–176].”