The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine

By P. Bianco, Xu Cao, P. Frenette, J. Mao, P. Robey, P. Simmons, Cun-Yu Wang. Nature Medicine, 2013

1,157 citations recorded by the source corpus.

Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/79dad7c26df6eea2b808749eb1e487e8ebdc9892

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Citations in the corpus

Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Still largely unsolved, the mystery of efficacy without long-term engraftment, especially in non-mesodermal tissues, remains a source of considerable debate [24, 25].”
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, background): “Following the description of such cells as holding multi-lineage potential (72), MSCs emerged as one of the most intensively studied non-haematopoietic adult stem cell entities (73,74).”
Mesenchymal stromal cells: clinical challenges and therapeutic opportunities (2018, background): “In the US in particular, industrial sponsors have led virtually all advanced phase III clinical trials of MSCs, and the field as a whole has been severely criticized for its ill-informed irrational exuberance(Bianco et al., 2013).”
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential (2015, background): “A prime candidate for the endogenous MSC has been the mesenchymal cells that surround the bone marrow sinusoids (Bianco et al., 2013).”
Bone substitutes in orthopaedic surgery: from basic science to clinical practice (2014, background): “It is noteworthy that naı̈ve undifferentiated MSCs are prone to environment-induced lineage commitment [186] meaning that they can undergo spontaneous osteogenic differentiation upon ‘‘in vivo’’ inoculation into a damaged bone [187, 176].”
Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells Current stage and future perspectives (2018, neutral): “is diminished by age, health or other factors [133].”