Context-dependent control of alternative splicing by RNA-binding proteins

By Xiang-Dong Fu, M. Ares. Nature reviews genetics, 2014

982 citations recorded by the source corpus.

Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative splicing, but it is not yet possible to read the 'splicing code' that dictates splicing regulation on the basis of genome sequence. Each alternative splicing event is controlled by multiple RBPs, the combined action of which creates a distribution of alternatively spliced products in a given cell type. As each cell type expresses a distinct array of RBPs, the interpretation of regulatory information on a given RNA target is exceedingly dependent on the cell type. RBPs also control each other's functions at many levels, including by mutual modulation of their binding activities on specific regulatory RNA elements. In this Review, we describe some of the emerging rules that govern the highly context-dependent and combinatorial nature of alternative splicing regulation.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/79ab749dfe7e595f3da2e173e80cdadf2a7989bd

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Citations in the corpus

• N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein (2017, background): “Given that the regulation of alternative splicing by RNA binding proteins is highly position-dependent (52), the role of HNRNPG in splicing regulation is likely to be strongly dependent on the relationship between its different RNA binding domains.”