Reverse Engineering of Biological Complexity

By M. Csete, John C. Doyle. Science, 2002

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Control, exploitation and tolerance of intracellular noise (2002, background): “Considerations of noise and robustness offer insight into the design and function of intracellular network”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “emicalstatesand kineticscheme of a molecular motor from its observed properties is reminiscent of inferring the operational mechanism of a given functioning macroscopic motor by “reverse engineering” [78, 79]. It would be desirable to follow Platt’s [80] principle of “strong inference” [81] which is”
Robustness of Cellular Functions (2004, neutral): “(Csete and Doyle, 2002).”
Robustness of Social-Ecological Systems: Implications for Public Policy (2013, background): “The engineered system of a Boeing 777 which has 150,000 different subsystem modules can continue to fly when many modules have been knocked out (Csete and Doyle, 2002).”
Explaining the Cambrian "Explosion" of Animals (2006, background): “It is easy to see why this perhaps counter-intuitive result occurs once one recognizes that an optimal solution for one need will typically compromise the ability of the organism to perform some other need, a principle well understood by engineers of complex systems (Csete & Doyle 2002).”