Increased levels of glutamate in brains from patients with mood disorders.

By K. Hashimoto, A. Sawa, M. Iyo. Biological Psychiatry, 2007

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Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “Evidence of increased glutamate (Matute et al., 2006, Hashimoto et al., 2007, Matute, 2011), as well as microglial activation and increased expression of QUIN (Steiner et al., 2008), have been found in the frontal cortex of patients with mood disorders.”
Towards a glutamate hypothesis of depression (2011, background): “…cortex glutamate concentrations (Francis et al., 1989), yet a more recent postmortem study of the frontal cortex showed a significant increase in tissue glutamate levels in individuals with major depressive and bipolar disorders after controlling for postmortem interval (Hashimoto et al., 2007).”
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders (2008, background): “A recent post-mortem study specifically controlling for the effects of post-mortem interval found increased levels of glutamate in the frontal cortex of patients with BPD and MD”