Monolithic integrated microfluidic DNA amplification and capillary electrophoresis analysis system

By E. Lagally, P. C. Simpson, R. Mathies. 2000

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Point-of-care microfluidic devices for pathogen detection (2018, background): “Effective development of diagnostic systems such as LOC and microfluidics requires ultrahigh sensitivity and specificity to enable real-time analysis needed for medical diagnosis (Beebe et al., 2000; Lagally et al., 2000).”
Digital microfluidics: is a true lab-on-a-chip possible? (2007, methodology): “While numerous studies of on-chip PCR have been reported on continuous-flow microfluidic chips (Lagally et al. 2000; Schneegass et al. 2001; Cady et al. 2004; Ottesen et al. 2006), much less work has been reported on electrowetting or electrostatic-based PCR devices (Tokoro et al.”
PCR microfluidic devices for DNA amplification. (2006, methodology): “…2003; Chaudhari et al., 1998; Daniel et al., 1998; Deshpande et al., 1999; Dunn et al., 2000; Friedman and Meldrum, 1998; Iordanov et al., 2003; Lagally et al., 2000, 2001a,b; Liao et al., 2005; Liu et al., 2003; Matsubara et al., 2005; Miao et al., 2003; Nagai et al., 2001a,b; Nakane et al.,…”
Micro total analysis system (μ-TAS) in biotechnology (2004, methodology): “These systems were further improved by the development of an integrated microfluidic device that combined stochastic PCR amplification of a single DNA template molecule with CE analysis of the products (Lagally et al. 2000, 2001).”