Human Skin Fungal Diversity
By Keisha Findley, Julia Oh, Joy Y. Yang, Sean Conlan, C. Deming, Jennifer A. Meyer, Deborah Schoenfeld, Effie Y. H. Nomicos, Morgan Park, H. Kong and 1 more. Nature, 2013
996 citations recorded by the source corpus.
Traditional culture-based methods have incompletely defined the microbial landscape of common recalcitrant human fungal skin diseases, including athlete’s foot and toenail infections. Skin protects humans from invasion by pathogenic microorganisms and provides a home for diverse commensal microbiota. Bacterial genomic sequence data have generated novel hypotheses about species and community structures underlying human disorders. However, microbial diversity is not limited to bacteria; microorganisms such as fungi also have major roles in microbial community stability, human health and disease. Genomic methodologies to identify fungal species and communities have been limited compared with those that are available for bacteria. Fungal evolution can be reconstructed with phylogenetic markers, including ribosomal RNA gene regions and other highly conserved genes. Here we sequenced and analysed fungal communities of 14 skin sites in 10 healthy adults. Eleven core-body and arm sites were dominated by fungi of the genus Malassezia, with only species-level classifications revealing fungal-community composition differences between sites. By contrast, three foot sites—plantar heel, toenail and toe web—showed high fungal diversity. Concurrent analysis of bacterial and fungal communities demonstrated that physiologic attributes and topography of skin differentially shape these two microbial communities. These results provide a framework for future investigation of the contribution of interactions between pathogenic and commensal fungal and bacterial communities to the maintainenace of human health and to disease pathogenesis.
Subfields: Dermatology, Epidemiology, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/792218a45b93b1d0b5359d5e2d761c4fc0c4aced
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In Epidemiology
Citations in the corpus
- Multiorganismal Insects: Diversity and Function of Resident Microorganisms (2014, background): “The extent to which cuticle-associated bacteria can proliferate and form stable communities, as occurs on human skin (46), is largely unknown.”
- EPA-ng: Massively Parallel Evolutionary Placement of Genetic Sequences (2018, neutral): “2012) as well as in diversity studies (Findley et al. 2013; Sunagawa et al. 2013).”
- The wound microbiota: microbial mechanisms of impaired wound healing and infection (2024, positive): “The skin microbiota varies greatly by topographical location on the body; thus, the site of incision likely determines the microbial composition at the incision 25 .”
- The healthy human microbiome (2016, background): “Trans-kingdom interactions are responsible for at least part of the ecological and immune balance of the healthy microbiome; for example, there is apparent competition between bacteria and fungi across skin biochemical environments [59] or in Lactobacillus control of fungi in the gut [55] and vagina”
- New evidences on the altered gut microbiota in autism spectrum disorders (2017, neutral): “8S1R: 5′-GTTCAAAGAYT CGATGATTCAC-3′) [62] containing adaptors, key”
- Scraping the bottom of the barrel: are rare high throughput sequences artifacts? (2015, methodology): “…OTU sequences were assigned to taxa in MOTHUR using the Na€ıve Bayesian Classifier (Wang et al., 2007) with the RDP 28s rRNA reference (v.7) or with two ITS databases, Findley (ITS1; Findley et al., 2013) and UNITE plus INSD non-redundant ITS database (ITS1 and ITS2; K~oljalg et al., 2013).”