Age-specific SARS-CoV-2 infection fatality ratio and associated risk factors, Italy, February to April 2020

By P. Poletti, M. Tirani, D. Cereda, F. Trentini, G. Guzzetta, V. Marziano, S. Buoro, Simona Riboli, L. Crottogini, Raffaella Piccarreta and 6 more. 2020

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We analysed 5,484 close contacts of coronavirus disease (COVID-19) cases in Italy, all tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection fatality ratio was 0.43% (95% confidence interval (CI): 0.21–0.79) for individuals younger than 70 years and 10.5% (95% CI: 8.0–13.6) for older individuals. Risk of death after infection was 62% lower (95% CI: 31–80) in clusters identified after 16 March 2020 and 1.8-fold higher for males (95% CI: 1.03–3.16).

Subfields: Infectious Diseases, Modeling and Simulation, Oncology