Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity.

By T. C. Long, Navid B. Saleh, R. Tilton, G. Lowry, B. Veronesi. Environmental Science and Technology, 2006

874 citations recorded by the source corpus.

Subfields: Materials Chemistry, Neurology

View Paper: https://www.semanticscholar.org/paper/7916f199034aa472b4c2653af6a99fc55e61918f

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In Materials Chemistry

In Neurology

G. Oberdörster

Citations in the corpus

Crystal structure mediates mode of cell death in TiO2 nanotoxicity (2009, background): “Nantoxicity studies examining the effects of TiO2 have shown induction of inflammatory responses, cytotoxicity, and reactive oxygen species (ROS) formation in a variety of cell types and tissues (Renwick et al. 2004; Warheit et al. 2006; Grassian et al. 2007; Sayes et al. 2006; Gurr et al. 2005; Lon”
Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus. (2008, background): “OS-mediated toxicity has been shown for TiO2 in in vitro studies, including brain cells (Long et al., 2006).”
A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives (2017, neutral): “The association of nanotechnology with green chemistry is thus allowing for the emergence of biologically and cytologically compatible metallic NPs [19,32].”
Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal-oxide nanoparticles. (2012, background): “However, (1)O2 was detected in the nAl2O3 and nSiO2 suspensions, as shown in Figure 2c, which indicates that nAl2O3 and nSiO2 may operate as a conduit for electrons similar to nTiO2 and promote photochemical reactions without illumination.(20,21)”
Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies (2009, background): “In many toxicological studies, the IS of the buffer solution to disperse nanoparticles for in vitro and in vivo tests is often higher than 0.1 M ( Long et al. 2006; Warheit et al. 2007; Sager et al. 2007; Murdock et al. 2008).”
Biosynthesis of Zinc Oxide Nanoparticles Using Ixora Coccinea Leaf Extract—A Green Approach (2016, background): “Recent studies have shown that nanoparticles of some materials including metal oxides, can induce cell death in eukaryotic cells [4]-[6] and growth inhibition in prokaryotic cells due to cytotoxicity.”
Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. (2007, background): “TiO2 NPs have also been shown to cause oxidative stress and injury to mouse microglial cells in vitro (Long et al., 2006).”