6-month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer: a randomized controlled trial.

By A. D'Amico, J. Manola, M. Loffredo, A. Renshaw, Alyssa DellaCroce, P. Kantoff. Journal of the American Medical Association (JAMA), 2004

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Guideline for the management of clinically localized prostate cancer: 2007 update. (2007, background): “Several pivotal randomized clinical trials related to prostate cancer treatment have been completed, including a chemoprevention study,(5) along with studies demonstrating prolongation of life in men with hormone-refractory metastatic disease 7 and improved outcomes in men with nonmetastatic disease”
Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion (2009, methodology): “At present, combined blockade is most commonly employed as a component of neoadjuvant and concurrent ADT with radiation therapy, and in intermittent androgen suppression”
Systematic Review: Comparative Effectiveness and Harms of Treatments for Clinically Localized Prostate Cancer (2008, background): “EBRT alone (1 RCT) [23] Medium More adverse effects, including gynecomastia and impotence, with ADT plus EBRT vs.”
Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer. (2008, background): “This is tempered by the fact that androgen ablation therapy has also been shown to be beneficial in the same patient group (24).”
Androgen suppression and radiation vs radiation alone for prostate cancer: a randomized trial. (2008, methodology): “AST use for PSA failureg Orchiectomy 4 (5) 0 0 1 (4)”