Modularity of intrinsic disorder in the human proteome

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Genome‐scale prediction of proteins with long intrinsically disordered regions (2014, background): “35,39 Importantly, knowledge of LDRs finds practical applications, as they are implicated in protein– protein recognition and are important for target selection in structural genomics.”
Protein design and variant prediction using autoregressive generative models (2021, background): “Indels make up 15 – 21% of human polymorphisms 41 – 43 , 44% of human proteins contain disordered regions longer than 30 amino acids 40,44 , and both are enriched in association with human diseases such as cystic ﬁ brosis, many cancers 45,46 , cardiovascular and neurodegenerative diseases, and…”
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. (2011, methodology): “Such sequences are structurally flexible and populate a range of conformational states from extended disordered to collapsed, molten globule-like structures (Dunker et al., 2008; Pentony and Jones, 2009).”