Functional connectivity in an fMRI working memory task in high-functioning autism

By H. Koshino, P. Carpenter, Nancy J. Minshew, V. Cherkassky, T. Keller, Marcel Adam Just. NeuroImage, 2005

628 citations recorded by the source corpus.

An fMRI study was used to measure the brain activation of a group of adults with high-functioning autism compared to a Full Scale and Verbal IQ and age-matched control group during an n-back working memory task with letters. The behavioral results showed comparable performance, but the fMRI results suggested that the normal controls might use verbal codes to perform the task, while the adults with autism might use visual codes. The control group demonstrated more activation in the left than the right parietal regions, whereas the autism group showed more right lateralized activation in the prefrontal and parietal regions. The autism group also had more activation than the control group in the posterior regions including inferior temporal and occipital regions. The analysis of functional connectivity yielded similar patterns for the two groups with different hemispheric correlations. The temporal profile of the activity in the prefrontal regions was more correlated with the left parietal regions for the control group, whereas it was more correlated with the right parietal regions for the autism group.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/78f5828abfc422641d02f3fb2e17e30cf5e44d1f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Psychiatry and Mental health

Eric Courchesne

Citations in the corpus

Investigating the predictive value of whole-brain structural MR scans in autism: A pattern classification approach (2010, background): “This may be of particular relevance to ASD, as individuals with the disorder most likely have abnormalities in the development of neural systems – rather than isolated regions – leading to differences in intra-regional correlations of brain metabolism, function and anatomy (Horwitz et al., 1988; Kos”
Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009, neutral): “This may result in further altered long-range connectivity [80, 81], vital for communication between neocortical modules and hemispheres [74, 82–85].”
Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception (2006, methodology): “…in Just et al., 2004) of significant diminished synchrony of activation among brain regions that were involved in a task, and there is some current latitude between a generalized (Just et al., 2004) vs. a localized (Koshino et al., 2005) interpretation of the broad concept of underconnectivity.”
A Typical Participation of Visual Cortex during Word Processing in Autism: An fMRI Study of Semantic Decision. (2007, result): “Together with the convergent results by Koshino et al. (2005) on verbal working memory described above, these findings suggest that individuals with ASD may rely on perception-based processing modes even after prolonged exposure to a given task, whereas control subjects tend to use such modes only…”
Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks (2012, neutral): “Functional connectivity has been investigated in block (e.g., Hampson et al., 2002; Koshino et al., 2005) and event-related (Aizenstein et al., 2009; Fox et al., 2006; Rissman et al., 2004; Siegle et al., 2007) fMRI activation designs.”
Diffusion tensor imaging of the corpus callosum in Autism (2007, neutral): “Interhemispheric functional underconnectivity has been suggested by several recent fMRI studies of autism in language processing and working memory (Just et al., 2004; Koshino et al., 2005, respectively).”
Inhibitory control in WM gate-opening: Insights from alpha desynchronization and norepinephrine activity under atDCS stimulation (2024, background): “The left inferior parietal cortices are likely essential for the updating of internal representations of the environmental context using incoming information (Geng and Vossel, 2013) and also act as an information buffer of WM (Koshino et al., 2005).”