The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

By Laura K. Mackay, A. Rahimpour, J. Ma, Nicholas Collins, Angus T Stock, Ming-Li Hafon, J. Vega‐Ramos, P. Lauzurica, Scott N. Mueller, T. Stefanovic and 5 more. Nature Immunology, 2013

1,247 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/788831534037746ff2931ade6047ad0ebffb8fc5

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In Immunology

1. Caroline L. Sokol
2. Brahma V. Kumar
3. J. Griffith
4. D. Farber
5. Y. Bryceson
6. A. Luster

Citations in the corpus

• Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, background): “…analysis (GSEA) (Subramanian et al., 2005) also revealed a strong enrichment of the differentially expressed genes in human CD4+CD69+ and CD8+CD69+ subsets within the gene signatures of TRMs from mouse brain (Wakim et al., 2012) and from mouse skin and lung (Mackay et al., 2013) (Figure 4B).”
• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “For example, the development of CD8+ TRM in the skin during HSV infection is dependent upon localization of CD8+ TRM precursors to the epidermis by CXCR3-CXCL10 interactions, which counteract a CCR7-dependent tissue exit signal (209).”
• CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin (2017, positive): “Similar to mouse CD8 Trm cells in the context of viral infection (Mackay et al., 2013; Wakim et al., 2013), the transcriptional profiles of human CD8CD103CD49a Trm cells suggested that anti-viral defense and target cell killing represent key functions of this subset.”