Drug combination studies and their synergy quantification using the Chou-Talalay method.

By T. Chou. Cancer Research, 2010

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SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets (2022, methodology): “Previously developed tools that can analyze drug combination synergy include COMPUSYSN [9], BRAID [10], Combenfit [11], SynergyFinder [12], and Synergy [13].”
Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data (2011, methodology): “in an iterative way, but they only work on small drug sets due to the computational and experimental cost. Mathematical modeling was used to determine synergistic combinations by comparing dose-response profiles of single agents against those of drug combinations”
Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model (2015, background): “As pointed out by many others [8 – 10], there is still no standardized guideline on how to choose the optimal reference model.”
Reconceptualizing synergism and antagonism among multiple stressors (2015, methodology): “For example, Christensen et al. (2006) observed a positive synergistic interaction for consumer biomass between raised temperature, droughtinduced UVB exposure and acidity in temperate lakes, despite each stressor individually exerting negative effects. Our classification approach, with its identifi”