Intracellular calcium dependence of transmitter release rates at a fast central synapse

By R. Schneggenburger, E. Neher. Nature, 2000

781 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7872dd9199cf265c66771399b1af1ad24bb1f4f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. T. Sūdhof
2. T. Sakaba
3. N. Brose
4. A. Morgan
5. Peter Jonas
6. E. Neher
7. Weiqi Zhang
8. Andrea Burgalossi

In Molecular Biology

1. T. Sūdhof
2. T. Sakaba
3. A. Morgan
4. R. Burgoyne
5. N. Brose
6. Peter Jonas
7. E. Neher
8. Weiqi Zhang

Citations in the corpus

• Patch-clamp recording from mossy fiber terminals in hippocampal slices (2006, methodology): “were used to determine the affinity of the Ca 2+ sensor of exocytosi”
• SNARE Protein Recycling by aSNAP and bSNAP Supports Synaptic Vesicle Priming (2010, methodology): “These findings are in accord with data on the role of Syt-2 in the calyx of Held (Sun et al., 2007) and on Syt-1 deficient autaptic cells (Liu et al., 2009).”
• Secretory granule exocytosis. (2003, background): “dependency in the low micromolar range (2–5 M) (86, 677) comparable to that for secretory granule exocytosis.”
• The synaptic vesicle cycle. (2004, neutral): “In both models, the Ca 2+ sensor contains 5 Ca 2+ -binding sites (Bollmann et al. 2000, Schneggenburger & Neher 2000).”
• Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+ Channels (2005, background): “Because of the high Ca 2 cooperativity and Ca 2 sensitivity of neurotransmitter release (Bollmann et al., 2000; Schneggenburger and Neher, 2000), regulating VDCCs efficiently controls synaptic strength, and small changes in Ca 2 influx lead to magnified effects on synaptic release (Felmy et al.”
• Multiple roles of calcium ions in the regulation of neurotransmitter release. (2008, methodology): “Amplitudes of [Ca2+] microdomains and their temporal halfwidths (Bollmann et al., 2000; Schneggenburger and Neher, 2000) as derived by step three of the ‘‘bioassay approach’’ are well compatible with the expectations of a diffusional model, if it is assumed that mean distances between vesicles and…”
• SNARE-mediated membrane fusion (2001, background): “The concentration of Ca 2+ that is sensed at the fusion site has been estimated to range from 25 μM at presynaptic terminal”