Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β

By J. Saharinen, J. Keski‐oja. 2000

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Making sense of latent TGFβ activation (2003, background): “Only the third of the four 8-cys domains within each of the LAP-binding LTBPs can disulfide bond to LAP (Saharinen and Keski-Oja, 2000); the other 8-cys domains may localize LTBPs to the ECM (Unsold et al., 2001).”
TGF-β Activation and Function in Immunity (2013, background): “Regulation by Other TGF-β-Binding Proteins As noted above, there are four members of the LTBP family, LTBP1, 2, 3, and 4, and three of these, LTBP1, 3, and 4, can form disulfide bonds with TGF-β LAPs prior to secretion in Annu Rev Immunol.”
Fibronectin is required for integrin o:vβ6‐mediated activation of latent TGF‐β complexes containing LTBP‐1 (2005, background): “LTBP-1, -3, and -4, but not LTBP-2, can disulfide bind to LAP through the third of the four 8-Cys domains ( 16 ).”