Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment.

By S. Scheff, D. Price, Frederick A. Schmitt, E. Mufson. Neurobiology of Aging, 2006

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Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models (2016, neutral): “Synaptic deficits occur in early AD and mild cognitively impaired patients before onset of plaques and are some of the first signs of the neuronal degenerative process (4, 23-25).”
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. (2016, background): “In humans, studies have identified synaptic loss as a correlate of, and a major contributor to, cognitive decline (Scheff et al., 2006; Robinson et al., 2014).”
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment (2010, background): “, 2006) and that is further compromised in AD (Hyman et al., 1986; Killiany et al., 2002; Scheff et al., 2006).”