Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

By S. Hua, M. B. de Matos, J. Metselaar, G. Storm. Frontiers in Pharmacology, 2018

812 citations recorded by the source corpus.

The use of nanotechnology in medicine has the potential to have a major impact on human health for the prevention, diagnosis, and treatment of diseases. One particular aspect of the nanomedicine field which has received a great deal of attention is the design and development of nanoparticulate nanomedicines (NNMs) for drug delivery (i.e., drug-containing nanoparticles). NNMs are intended to deliver drugs via various mechanisms: solubilization, passive targeting, active targeting, and triggered release. The NNM approach aims to increase therapeutic efficacy, decrease the therapeutically effective dose, and/or reduce the risk of systemic side effects. In order to move a NNM from the bench to the bedside, several experimental challenges need to be addressed. This review will discuss the current trends and challenges in the clinical translation of NNMs as well as the potential pathways for translational development and commercialization. Key issues related to the clinical development of NNMs will be covered, including biological challenges, large-scale manufacturing, biocompatibility and safety, intellectual property (IP), government regulations, and overall cost-effectiveness in comparison to current therapies. These factors can impose significant hurdles limiting the appearance of NNMs on the market, irrelevant of whether they are therapeutically beneficial or not.

Subfields: Biomaterials, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/78448712ea94786b3b386bdba8bf6969876ff91b

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Citations in the corpus

• Green Synthesis of Metallic Nanoparticles: Applications and Limitations (2021, background): “The chemical methods are economical for large-scale production; however, the use of toxic chemicals and production of harmful by-products cause environmental damage, thereby limiting its clinical and biomedical applications [16,17].”