Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta
By Robert Kleffner, Jeff Flatten, Andrew Leaver-Fay, David Baker, Justin B. Siegel, Firas Khatib, Seth Cooper. 2017
101 citations recorded by the source corpus.
Summary : Foldit Standalone is an interactive graphical interface to the Rosetta molecular modeling package. In contrast to most command‐line or batch interactions with Rosetta, Foldit Standalone is designed to allow easy, real‐time, direct manipulation of protein structures, while also giving access to the extensive power of Rosetta computations. Derived from the user interface of the scientific discovery game Foldit (itself based on Rosetta), Foldit Standalone has added more advanced features and removed the competitive game elements. Foldit Standalone was built from the ground up with a custom rendering and event engine, configurable visualizations and interactions driven by Rosetta. Foldit Standalone contains, among other features: electron density and contact map visualizations, multiple sequence alignment tools for template‐based modeling, rigid body transformation controls, RosettaScripts support and an embedded Lua interpreter. Availability and Implementation: Foldit Standalone is available for download at https://fold.it/standalone, under the Rosetta license, which is free for academic and non‐profit users. It is implemented in cross‐platform C ++ and binary executables are available for Windows, macOS and Linux. Contact: scooper@ccs.neu.edu
Subfields: Materials Chemistry, Molecular Biology
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Citations in the corpus
- Repurposing Citizen Science Games as Software Tools for Professional Scientists (2018, background): “Foldit , a game in which players predict the structures of naturally-occurring proteins and design synthetic proteins [8] was restructured into a separate stand-alone, offline application for protein structure manipulation, called Foldit Standalone [26].”
- Creating Custom Foldit Puzzles for Teaching Biochemistry (2019, methodology): “…of Foldit including “ template contests, ” which allow users to administer their own puzzles, selecting from a small list of prede fi ned simple examples, and Foldit Standa-lone [6], an application version of Foldit that allows users to load in their own structures but not run them as puzzles.”