Beta-catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2

By Shelby A. Blythe, P. S. Klein. 2009

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Arginine Methylation: The Coming of Age. (2017, background): “Argininemethylation is known to play amajor role in gene regulationbecauseof theability of thePRMTs todeposit keyactivating (histone H4R3me2a, H3R2me2s, H3R17me2a, H3R26me2a) or repressive (H3R2me2a, H3R8me2a, H3R8me2s, H4R3me2s) histone marks.”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “In early Xenopus embryos, prior to the mid-blastula transition, b-catenin occupies silent genes and establishes poised chromatin states that are necessary for later transcription (Blythe et al. 2010).”
Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition (2011, background): “b-catenin is required at or before the 32 cell stage to poise siamois and xnr3 for activation and helps to establish this poised state by recruiting the histone methyltransferase Prmt2 to the promoters of these genes [25].”