Mechanisms of free radical-induced damage to DNA
By M. Dizdaroglu, P. Jaruga. Free radical research, 2012
662 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology, Pollution
View Paper: https://www.semanticscholar.org/paper/09b184c2af1fd95c84d9a89918482468316edbeb
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In Molecular Biology
- Ruixue Huang
- Xiaoying Chen
- Pingkun Zhou
- Jianlong Wang
- T. Vlachogianni
- Michael Schieber
- Navdeep S. Chandel
- A. Valavanidis
In Oncology
In Pollution
Citations in the corpus
- Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “HO· reacts with the heterocyclic DNA nucleobases and the sugar moiety near or at diffusion-controlled rates leading to adduct radicals [92–95].”
- Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. (2013, background): “For a typical therapeutic dose of around 2 Gy/fraction of sparsely ionising radiation, about 3000 DNA lesions are produced per cell exposed, a level of damage far lower than the level of up to 50 000 lesions produced daily through ROS.”
- Removal of antibiotic resistance genes (ARGs) in various wastewater treatment processes: An overview (2020, background): “These free radicals subsequently cause indirect damage of the cells through oxidation and reduction way, leading to the metabolic disturbance, DNA fragmentation, and eventually the deactivation of the ARGs (Dizdaroglu & Jaruga, 2012; Wang & Wang, 2007).”
- ROS Function in Redox Signaling and Oxidative Stress (2014, background): “The third type of ROS is the extremely reactive hydroxyl radical, which indiscriminately oxidizes lipids, proteins, and DNA, resulting in damage or genomic instability [12].”
- DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “Sugar damage, such as 8,5′-cyclopurine-2′deoxynucleosides, can be caused by free radical insult to the sugar moiety.(103,104) DNA cross-linking is often attributed to exposure to chemical cross-linking agents, e.”