Clinical features and treatment of COVID‐19 patients in northeast Chongqing
By S. Wan, Y. Xiang, Wei Fang, Yu Zheng, Boqun Li, Yanjun Hu, Chunhui Lang, Daoqiu Huang, Qiuyan Sun, Y. Xiong and 7 more. Journal of Medical Virology, 2020
922 citations recorded by the source corpus.
The outbreak of the novel coronavirus in China (SARS‐CoV‐2) that began in December 2019 presents a significant and urgent threat to global health. This study was conducted to provide the international community with a deeper understanding of this new infectious disease. Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. A total of 135 hospitalized patients with COVID‐19 were enrolled. The median age was 47 years (interquartile range, 36‐55), and there was no significant gender difference (53.3% men). The majority of patients had contact with people from the Wuhan area. Forty‐three (31.9%) patients had underlying disease, primarily hypertension (13 [9.6%]), diabetes (12 [8.9%]), cardiovascular disease (7 [5.2%]), and malignancy (4 [3.0%]). Common symptoms included fever (120 [88.9%]), cough (102 [76.5%]), and fatigue (44 [32.5%]). Chest computed tomography scans showed bilateral patchy shadows or ground glass opacity in the lungs of all the patients. All patients received antiviral therapy (135 [100%]) (Kaletra and interferon were both used), antibacterial therapy (59 [43.7%]), and corticosteroids (36 [26.7%]). In addition, many patients received traditional Chinese medicine (TCM) (124 [91.8%]). It is suggested that patients should receive Kaletra early and should be treated by a combination of Western and Chinese medicines. Compared to the mild cases, the severe ones had lower lymphocyte counts and higher plasma levels of Pt, APTT, d‐dimer, lactate dehydrogenase, PCT, ALB, C‐reactive protein, and aspartate aminotransferase. This study demonstrates the clinic features and therapies of 135 COVID‐19 patients. Kaletra and TCM played an important role in the treatment of the viral pneumonia. Further studies are required to explore the role of Kaletra and TCM in the treatment of COVID‐19.
Subfields: Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/778fa4ebca543194363b13b3b15a38515ae04ea3
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Citations in the corpus
- Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms (2020, neutral): “However, retrospective studies suggest corticosteroids are not uncommonly used to treat hospitalized COVID-19 patients Mo et al., 2020; Wan et al., 2020) .”
- Smoking Is Associated With COVID-19 Progression: A Meta-analysis (2020, positive): “Two studies 14 16 categorized the outcome as severe (respiratory distress with respiratory rate ≥30/min, or oxygen saturation ≤93% at rest, or oxygenation index ≤300 mmHg , based on the diagnostic and treatment guideline for SARS-CoV-2 issued by Chinese National Health Committee 16 ) or mild, three…”
- Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis (2020, neutral): “Wan S [65] 21-Mar-20 32198776 Multi-centre in Chongqing, China 9”
- Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study (2020, background): “According to the clinical studies from Asia, the most prevalent symptoms consist of fever, cough, dyspnea, sputum production, myalgia, arthralgia, headache, diarrhea, rhinorrhea, and sore throat [4, 5] .”
- Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis (2020, neutral): “2020 [12] Retrospective Chongqing, China 135 72/135 (53.”
- Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression (2020, positive): “Subgroup analysis showed that DM was associated with mortality (RR 2. 12 ”