Comprehensive transcriptional map of primate brain development
By Trygve E Bakken, Jeremy A. Miller, S. Ding, Susan Sunkin, Kimberly A. Smith, Lydia Ng, A. Szafer, R. Dalley, J. Royall, Tracy A. Lemon and 89 more. 2016
351 citations recorded by the source corpus.
The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey.
Subfields: Molecular Biology, Computational Biology & Bioinformatics, Neuroscience
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Rahul Satija
- Nir Yosef
- John C. Marioni
- Martin Hemberg
- Allon Wagner
- Ewan Birney
- Ehud Y. Shapiro
- Berthold Göttgens
In Computational Biology & Bioinformatics
In Neuroscience
Citations in the corpus
- The Next Decade in AI: Four Steps Towards Robust Artificial Intelligence (2020, background): “More than 90% of our genome is expressed in the development of the brain (Miller et al., 2014; Bakken et al., 2016), and a significant number of those genes are expressed selectively in particular areas, giving rise to detailed initial structure.”
- Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults (2018, neutral): “To compare laser capture microdissected rhesus macaque samples to gross human hippocampus samples, we calculated average expression over all hippocampus samples for each age 33,34 .”
- The Human Cell Atlas (2017, background): “…it is surprisingly challenging to obtain definitive answers for most human genes beyond tissue- or organ-level resolution (although there have been pioneering efforts for the brain and immune system in mouse (Bakken et al., 2016; Hawrylycz et al., 2012; Kim and Lanier, 2013; Miller et al., 2014).”