Phytohemagglutinin-induced skin swelling in birds : histological support for a classic immunoecological technique

By Lynn B. Martin, P. Han, J. Lewittes, J. Kuhlman, K. Klasing, Martin Wikelski. 2006

457 citations recorded by the source corpus.

Subfields: Infectious Diseases, Parasitology

View Paper: https://www.semanticscholar.org/paper/7727b7d714688d20e195fd625f32455aceadf284

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Dennis Hasselquist
2. L. Tummeleht

In Parasitology

1. L. Tummeleht
2. Dennis Hasselquist
3. K. McGraw
4. E. Clotfelter
5. D. Ardia
6. J. Owen
7. F. Moore
8. R. M. Cox

Citations in the corpus

• Swainson’s thrushes in migratory disposition exhibit reduced immune function (2008, background): “PHA induces dermal infiltration of leukocytes, macrophages and thrombocytes, causing increased swelling of the tissue at the inoculation site (Stadecker et al. 1977; Goto et al. 1978; McCorkle et al. 1980; Martin et al. 2006).”
• Experimental evidence for physiological costs underlying the trade-off between reproduction and survival. (2010, background): “swelling at the site of injection (Martin et al. 2006).”
• Physiological mechanisms mediating costs of immune responses: what can we learn from studies of birds? (2012, background): “Administration of PHA will trigger both the innate immune system and the (unspecific) cellmediated arm of the adaptive immune system (Goto et al. 1978), the relative importance of these two systems for the reaction differing between species (Martin et al. 2006).”
• Red fish, blue fish: trade-offs between pigmentation and immunity in Betta splendens (2007, methodology): “We assessed generalized cell-mediated immunity using exposure to PHA, measured as an inflammatory response (Martin et al. 2006).”
• Measuring amphibian immunocompetence: validation of the phytohemagglutinin skin‐swelling assay in the cane toad, Rhinella marina (2011, background): “Thus, a smaller swelling may not necessarily indicate lower immunocompetence (Kennedy & Nager 2006; Martin et al. 2006), but rather reflect selection having favoured relatively greater investment into the humoral rather than the cell-mediated immune system (Lee 2006).”
• Functional analysis of the skin‐swelling response to phytohaemagglutinin (2010, background): “Based on information obtained by the few studies that attempted to clarify these immunological processes we are aware that the response is highly complex, involving both cells of the adaptive and innate immunity (Goto et al. 1978; McCorkle, Olah & Glick 1980; Martin et al. 2006).”
• Comparative immunoecology in birds: hypotheses and tests (2007, methodology): “…immunity and inflammation responses [that is one important component determining the amount of swelling induced by a phytohaemagglutinin (PHA) injection in the wing web skin; Martin et al. 2006a] are upheld in males because these responses are essential for healing wounds (Zuk and Johnsen 1998).”
• Physiological condition and immune function in great tits (Parus major L.): sources of variation and trade-offs in relation to growth (2006, background): “Maxwell & Robertson 1998) and the cutaneous hypersensitivity reaction induced by PHA last less than a week (e.g. Stadecker et al. 1977; McCorkle et al. 1980; Martin et al. 2006).”
• Host condition and host immunity affect parasite fitness in a bird–ectoparasite system (2007, background): “…widely used as a general measure of immunocompetence in avian ecological research, (see e.g. Smits et al. 1999; Tella, Scheuerlein & Ricklefs 2002; Martin et al. 2006 for reviews), but it can obviously only assess a limited aspect of the very complex vertebrate immune system (Klein 1993; Martin…”