The conception of the ABCD study: From substance use to a broad NIH collaboration
By Nora D. Volkow, G. Koob, R. Croyle, Diana W. Bianchi, J. Gordon, W. Koroshetz, E. Pérez-Stable, W. Riley, M. Bloch, K. Conway and 12 more. Developmental Cognitive Neuroscience, 2017
835 citations recorded by the source corpus.
Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it. Recent advances in neuroimaging, informatics, and genetics technologies have made it feasible to conduct a study of sufficient size and scope to answer many outstanding questions. At the same time, several Institutes across the NIH recognized the value of collaborating in such a project because of its ability to address the role of biological, environmental, and behavioral factors like gender, pubertal hormones, sports participation, and social/economic disparities on brain development as well as their association with the emergence and progression of substance use and mental illness including suicide risk. Thus, the Adolescent Brain Cognitive Development study was created to answer the most pressing public health questions of our day.
Subfields: Cognitive Neuroscience, Health, Toxicology and Mutagenesis, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/76c9b44f6e1101334945bad26d4a97eff72765a2
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In Cognitive Neuroscience
- Stephen M. Smith
- Thomas E. Nichols
- Bradley L. Schlaggar
- Olaf Sporns
- Randy L. Buckner
- David C. Van Essen
- Essa Yacoub
- Deanna M. Barch
In Health, Toxicology and Mutagenesis
In Psychiatry and Mental health
- Naomi P. Friedman
- Randy L. Buckner
- Trevor W. Robbins
- Stephen M. Smith
- Deanna M. Barch
- Bradley L. Schlaggar
- J. Dalley
- Abraham Z. Snyder
Citations in the corpus
- Statistical Challenges in "Big Data" Human Neuroimaging. (2018, positive): “Similarly the ABCD study (Volkow et al. 2017) uses a stratified design, sampling schools around the country, and children within each school, which must be accounted when analyzing its data.”
- The role of prefrontal cortex in cognitive control and executive function (2021, background): “As developmental studies are also likely to be of increasing importance for determining the factors influencing the etiology of mental disorders, large scale longitudinal studies of CC/EF, combined with sensitive clinical scales, trait questionnaires, neuroimaging, and genotyping, as for example, in”
- The Lifespan Human Connectome Project in Development: A large-scale study of brain connectivity development in 5–21 year olds (2018, positive): “Sex steroids can be assayed from hair using an extraction step and a simple enzyme-immunoassay with a commercially available kit (Gao et al., 2013; Wheeler, 2006).”