The 500 Dalton rule for the skin penetration of chemical compounds and drugs

By J. Bos, M. Meinardi. Experimental Dermatology, 2000

1,360 citations recorded by the source corpus.

Subfields: Dermatology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/76aac46639316df0ebc13c027beccfa14c5f87a2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. Geoffrey D. Miller
2. Carol S. Lim
3. B. Bruno

In Pharmaceutical Science

1. Gary P. Martin
2. Geoffrey D. Miller
3. Marc B. Brown
4. Stuart A. Jones
5. Carol S. Lim
6. B. Bruno
7. Franklin K. Akomeah

Citations in the corpus

• Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects (2006, background): “• A molecular weight less than 500 Da is essential to ensure ease of diffusion across the SC (Bos and Meinardi 2000), since solute diffusivity is inversely related to its size.”
• Basics and recent advances in peptide and protein drug delivery (2013, positive): “Historically, it has been demonstrated that the skin tends to keep out drug molecules greater than 500 Da [137], especially those molecules of hydrophilic nature [138].”