The nature of systems biology.

By Frank J. Bruggeman, Hans V. Westerhoff. Trends in Microbiology, 2007

561 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/76a448fc3a55896121c3f8ca892782d761e46447

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Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems (2016, background): “Defining the mathematical relationships between genes within a cellular process has been the focus of ‘‘bottom-up’’ systems biology (Bruggeman and Westerhoff, 2007; Chen et al., 2010).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “The nature of the forward-inverse problems and the bottom-up, top-down modeling strategies needed for integrating motors at different levels have some similarities, at least in spirit, with those followed in systems biology [94, 95, 96, 97, 98] and in the more ambitious physisome project [99].”
Milk Protein Synthesis in the Lactating Mammary Gland: Insights from Transcriptomics Analyses (2012, methodology): “Whereas, the bottom-up approach relies on developing automated tools based on a mathematical model, the topdown approach encompasses data processing from ‘omics’ studies to pathways and individual genes of an organism [42].”
Yeast Two-Hybrid, a Powerful Tool for Systems Biology (2009, unknown): “Systems bioenergetics holds the promise of integrating the multiple aspects of cellular energetics in a holistic approach which: (i) extends our knowledge on protein complexes involved in metabolic control and cell signalling [7], (ii) considers cellular compartmentation particularly important in th”
The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment (2015, background): “The control of flux through such biochemical networks is likely to be determined at multiple steps, rather than by a single ‘ratelimiting’ process (Kacser and Burns, 1973; Fell, 1997; Bruggeman and Westerhoff, 2007).”
The Logic of Chance: The Nature and Origin of Biological Evolution (2011, background): “The reality of the current, early stage in the progression of this research field is that efforts in systems biology largely amount to collection of extensive “omic” data, including transcriptomes (the complete set of transcripts for a given cell, tissue, or organism), proteomes (the complete set of”
Chapter 1. General introduction (2015, unknown): “…books Built by scientists, for scientists 12.2% 117,000 130M TOP 1%154 4,400 Chapter 1 General Introduction: Advances in Hepatic Surgery J.H.M.B. Stoot, R.J.S. Coelen, J.L.A. van Vugt and C.H.C. Dejong Additional information is available at the end of the chapter http://dx.doi.org/10.5772/54710”