Development and characterisation of chitosan nanoparticles for siRNA delivery.

By Haliza Katas, H. Alpár. Journal of Controlled Release, 2006

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Chitosan-based formulations for delivery of DNA and siRNA. (2010, methodology): “Stability studies revealed that chitosannanoparticleswere stable in medium containing up to 10% serum for chitosan–siRNA complexes and chitosan–TPP–siRNA nanoparticles [75].”
Chitosan—A versatile semi-synthetic polymer in biomedical applications (2011, background): “Chitosan–TPP nanoparticles with entrapped siRNA had better vectors than chitosan–siRNA complexes; this may be due to their high binding capacity and loading efficiency the chitosan–TPP nanoparticles appear to have good potential as viable vector candidates with safer and costeffective siRNA delivery”
Antibacterial effects of chitosan–tripolyphosphate nanoparticles: impact of particle size molecular weight (2014, background): “Smaller particle size was predicted on the basis of the low molecular weight and lower concentration on the basis of the reduced viscosity, which led to increased chitosan solubility in acetic acid, compared to high molecular weight and higher concentration (Katas and Alpar 2006; Morris et al. 2011;”
Perspectives for nano-biotechnology enabled protection and nutrition of plants. (2011, positive): “Chitosan NPs (b500 nm) with entrapped siRNA performed well as vectors for siRNA delivery vehicles (Katas and Alpar, 2006).”