The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
By Stephanie A. Studenski, K. Peters, D. Alley, P. Cawthon, R. McLean, Tamara B. Harris, Luigi Ferrucci, Jack M. Guralnik, Maren S Fragala, A. Kenny and 5 more. The journals of gerontology. Series A, Biological sciences and medical sciences, 2014
2,230 citations recorded by the source corpus.
Background. Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based on clinically relevant thresholds and independently validated. The Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project used an evidence-based approach to develop these criteria. Initial findings were presented at a conference in May 2012, which generated recommendations that guided additional analyses to determine final recommended criteria. Details of the Project and its findings are presented in four accompanying manuscripts. Methods. The Foundation for the National Institutes of Health Sarcopenia Project used data from nine sources of community-dwelling older persons: Age, Gene/Environment Susceptibility-Reykjavik Study, Boston Puerto Rican Health Study, a series of six clinical trials, Framingham Heart Study, Health, Aging, and Body Composition, Invecchiare in Chianti, Osteoporotic Fractures in Men Study, Rancho Bernardo Study, and Study of Osteoporotic Fractures. Feedback from conference attendees was obtained via surveys and breakout groups. Results. The pooled sample included 26,625 participants (57% women, mean age in men 75.2 [±6.1 SD] and in women 78.6 [±5.9] years). Conference attendees emphasized the importance of evaluating the influence of body mass on cutpoints. Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 for men and <0.512 for women. Conclusions. These evidence-based cutpoints, based on a large and diverse population, may help identify participants for clinical trials and should be evaluated among populations with high rates of functional limitations.
Subfields: Geriatrics and Gerontology, Physiology
View Paper: https://www.semanticscholar.org/paper/769ce3a9afa8cd7bb50e9aada4417c53416cf004
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Geriatrics and Gerontology
In Physiology
Citations in the corpus
- Sarcopenia: revised European consensus on definition and diagnosis (2018, background): “…kg Dodds (2014) [26] Chair stand >15 s for five rises Cesari (2009) [67] EWGSOP2 sarcopenia cut-off points for low muscle quantity ASM <20 kg <15 kg Studenski (2014) [3] ASM/height2 <7.0 kg/m2 <6.0 kg/m2 Gould (2014) [125] EWGSOP2 sarcopenia cut-off points for low performance Gait speed ≤0.8 m/s…”
- GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community (2019, background): “Assessment of muscle strength should be an integral measure in assessment of patients with suspected sarcopenia since impairment of muscle strength is now recognized as a key component for diagnosis of sarcopenia.(15,16) Though inflammatory mediators and other mechanisms besides malnutrition are at ”
- Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis (2019, result): “This highlights the importance of muscle strength or physical performance in the sarcopenia definition, in line with current definitions.(58,59,61,62,68,93) However, literatures also showed the value of including muscle mass in sarcopenia definitions.”
- GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community. (2019, methodology): “…of recommended cut-off values for muscle mass reductions, GLIM refers to recommendations from the European Working Group on Sarcopenia in Older People (EWGSOP) [15] and from The Foundation of National Institute of Health (FNIH) initiative [16], and the Asian Working Group on Sarcopenia (AWGS) [17].”
- ESPEN guideline on clinical nutrition in the intensive care unit. (2019, neutral): “Sarcopenia is defined as a decrease in muscle loss and/or function and is frequent in undernourished patients admitted to the ICU [27].”
- Epidemiology of sarcopenia: Prevalence, risk factors, and consequences. (2023, background): “There are also other definitions for sarcopenia, including the International Working Group on Sarcopenia (IWGS) [10] and the Foundation for the National Institute of Health (FNIH) [11].”
- Pitfalls in the measurement of muscle mass: a need for a reference standard (2018, positive): “However, more recently, the ratio of appendicular skeletal muscle mass divided by BMI is also being suggested.(8) Regardless of the choice of outcome measure for clinical trials of sarcopenia, precise methodology is available for the assessment of lean mass, and this may serve as a key defining char”
- Sarcopenia in daily practice: assessment and management (2016, methodology): “Using a different approach, the FNIH sarcopenia project [7] has also recently defined cut-offs for appendicular lean mass adjusted for body mass index (BMI), giving values of < 0.”