Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

By R. Mckernan, T. Rosahl, D. Reynolds, C. Sur, K. Wafford, J. Atack, S. Farrar, J. Myers, G. Cook, P. Ferris and 13 more. Nature Neuroscience, 2000

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International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “Genetically engineered mice (knockout and knockin) provide some evidence indicating that certain oligomeric receptors really do exist because one can correlate the loss of certain receptor responses and behaviors with the receptor subtypes addressed (Jones et al., 1997; Rudolph et al., 1999; McKerna”
Neonatal development of the rat visual cortex: synaptic function of GABAa receptor α subunits (2002, methodology): “Finally, also variations in the kinetics of GABA in the synaptic cleft may affect GABAA receptor kinetics (Draguhn & Heinemann, 1996; Nusser et al. 2001).”