Subunit arrangement and function in NMDA receptors

By Hiro Furukawa, Satinder K. Singh, R. Mancusso, Eric Gouaux. Nature, 2005

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Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “The intersubunit D1-D1 contacts formed across the dimer interface constrain D1 movement (Horning and Mayer, 2004; Furukawa et al., 2005; Mayer, 2005; Naur et al., 2007; Sobolevsky et al., 2009).”
Regulation of extrasynaptic signaling by polysialylated NCAM: Impact for synaptic plasticity and cognitive functions (2017, background): “The binding site for glutamate is located in the GluN2 subunit (Furukawa et al., 2005), whereas glycine and D-serine bind to the strychnine-insensitive NMDAR glycine binding site in theGluN1 subunit of NMDARs.”
NMDA receptor subunits: function and pharmacology. (2007, background): “the architecture of the ABD dimer between NMDARs and AMPARs [9 ], it is tempting to speculate that the NMDAR ABD dimer interface could also be a locus for allosteric modulation.”
Handbook of ion channels (2015, background): “The NMDA pore region should be twofold symmetric, because it is an obligate heterotetramer (Furukawa et al., 2005) with 2 GluN1 and 2 GluN2 subunits diametrically opposed (in the LBD layer; Riou et al.”