Interpreting thresholds for a clinically significant change in health status in asthma and COPD

By P. Jones. European Respiratory Journal, 2002

619 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

St. George's Respiratory Questionnaire: MCID (2005, methodology): “In two studies, one in asthma (11) the other in COPD (1), patients’ judgment of treatment efficacy at the end of the study were related to the change in SGRQ score over the study period.”
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. (2009, background): “The comparator for validation of asthma control measures has often been a ‘‘global physician assessment,’’ but this may not provide an absolute standard (71).”
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. (2006, background): “Both the CRQ and SGRQ have shown beneficial change after pulmonary rehabilitation (76, 305– 307), and both have established thresholds for clinical significance (308, 309).”
Maintenance therapy with budesonide and formoterol in chronicobstructive pulmonary disease (2003, background): “Budesonide/formoterol treatment was associated with the largest difference in the SGRQ Total score compared with placebo, which clearly exceeded the minimum clinically important difference of 4 units [ 19 ].”