Cytokine Storms: Understanding COVID-19

By N. Mangalmurti, Christopher A. Hunter. Immunity, 2020

619 citations recorded by the source corpus.

Summary The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in “ideal” responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/75fe64873b28a4b76063e246d10eba4481f6e9f2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. A. Aschenbrenner
2. T. Hirano
3. Joachim L. Schultze

In Molecular Biology

1. A. Aschenbrenner
2. T. Hirano
3. Joachim L. Schultze

Citations in the corpus

• IL-6 in inflammation, autoimmunity and cancer (2020, background): “Consistent with the notion that severe COVID-19 is a cytokine storm syndrome (12–17, 336 ), SARS-CoV-1 and MERS-CoV activate NF-κ B in a manner dependent on MyD88 through PRRs, such as retinoic acid-inducible gene I protein (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), leading…”
• COVID-19 and the human innate immune system (2021, background): “On the other hand, the definition of cytokine storm has expanded to conditions beyond sepsis and, irrespective of absolute cytokine concentrations, to include all inflammatory conditions with elevated circulating cytokines that result in systemic inflammation as well as secondary organ dysfunction (”