Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies

By B. Diniz, M. Butters, S. Albert, M. Dew, Charles F. Reynolds III. British Journal of Psychiatry, 2013

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Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014, background): “…meta-analysis studies have linked depression and AD (Chen et al., 1999; Charlson and Peterson, 2002; Ownby et al., 2006; Lenoir et al., 2011; Diniz et al., 2013), and several even consider late-life depression a signiﬁcant risk factor for future development of AD (Butters et al., 2000,…”
The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention (2021, positive): “Depression was a significant risk for AD (OR 1.65, 95% CI 1.42-1.92) (24).”
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders (2015, background): “Late onset depression is associated with greater neuropsychological deficit, more brain imaging abnormalities and increased risk for dementia (Diniz et al., 2013; Hickie et al., 2005; Salloway et al., 1996).”