Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses

By T. Hayes, Atif Collins, Melissa Lee, M. Mendoza, Nigel C. Noriega, A. Stuart, A. Vonk. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,224 citations recorded by the source corpus.

Subfields: Global and Planetary Change, Health, Toxicology and Mutagenesis, Pollution

View Paper: https://www.semanticscholar.org/paper/75e972c620376ddd912e3b3edd0eaf2d9212eeb8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Global and Planetary Change

1. Andrew Storfer
2. T. Beebee
3. R. Griffiths
4. A. Blaustein
5. J. Hero
6. A. Hatch
7. Joseph Kiesecker
8. Jason Rohr

In Health, Toxicology and Mutagenesis

1. T. Hayes
2. J. Hero
3. E. Clotfelter
4. A. Bell
5. Kate R. Levering
6. Jason Rohr
7. K. Kriger

In Pollution

1. T. Hayes
2. B. Darvas
3. E. Clotfelter
4. A. Bell
5. Kate R. Levering
6. Andras Szekacs

Citations in the corpus

• The role of animal behaviour in the study of endocrine-disrupting chemicals (2004, positive): “For example, Hayes et al. (2002a) showed that the gonadal development of male leopard frogs, Rana pipiens, was retarded at low, environmentally relevant concentrations of the popular herbicide atrazine but not REVIEW 467 at high concentrations.”
• Synergistic and antagonistic effects of atrazine on the toxicity of organophosphorodithioate and organophosphorothioate insecticides to Chironomus tentans (Diptera: Chironomidae) (2004, background): “In spite of its extensive use, atrazine is considered to be a relatively safe herbicide with a short half-life and insignificant bioaccumulation and biomagnification [4, 7 ].”
• Increasing Cropping System Diversity Balances Productivity, Profitability and Environmental Health (2012, background): “Declines in weed seedbanks reflected a focus of management attention on the timing of weed management activities and herbicide choices in all three systems, as well as the increased number and diversity of stress and mortality factors present in the 3-yr and 4-yr rotations [8,21].”
• Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. (2002, background): “Further, we showed that atrazine induced hermaphroditism at concentrations of only 0.1 ppb (Hayes et al. 2002) when administered throughout larval development.”
• The amphibian decline crisis: A watershed for conservation biology? (2005, background): “Atrazine, a widely applied herbicide, may cause feminisation of frogs at extremely low concentrations (<1 part per billion in pond water; Hayes et al., 2002a,b).”
• Forty Years with Glyphosate (2012, background): “It may not be surprising, therefore, that after atrazine (Hayes et al., 2002; 2010), glyphosate is the second herbicide active ingredient that is questioned due to its detrimental effects on the animal class, considered the most endangered on Earth, amphibians.”
• Will climate change reduce the effects of a pesticide on amphibians?: partitioning effects on exposure and susceptibility to contaminants (2011, background): “…exposure to atrazine can be delayed and might even be permanent, such as effects on the endocrine system, gonadal development, behavior, and survival (Stoker et al., 1999; Cooper et al., 2000; Hayes et al., 2002; Hayes et al., 2003; Rayner et al., 2005; Rohr & Palmer, 2005; Rohr et al., 2006b).”
• Amphibian declines: future directions (2003, background): “Male African clawed frogs exposed to atrazine had a significantly smaller larynx than control males (Hayes et al., 2002), suggesting that they may not be able to call as loudly as unexposed males, and thus not attract mates as well.”
• Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis) (2010, methodology): “Although a few studies suggest that atrazine has no effect on amphibians under certain laboratory conditions (29, 30), in other studies, atrazine reduces testicular volume; reduces germ cell and Sertoli cell numbers (11); induces hermaphroditism (6, 8, 10); reduces testosterone (10); and induces tes”
• Herpetofauna de serrapilheira da Reserva Florestal de Morro Grande, Cotia (SP) (2006, background): “Em alguns casos, quantidades mínimas dissolvidas podem provocar problemas de desenvolvimento em anfíbios relacionados a feminilização dos machos (Hayes et al. 2002).”
• Sydney Harbour: a review of anthropogenic impacts on the biodiversity and ecosystem function of one of the world’s largest natural harbours (2015, background): “Contamination is linked to impairments in development and reproduction of several species (Miskiewicz and Gibbs 1994; Hayes et al. 2002), emergence of diseases (Kiesecker 2002) and declines in diversity and ecosystem function (Johnston and Roberts 2009; Johnston et al.”
• Climatic Risk and Distribution Atlas of European Bumblebees (2015, background): “Several alternative factors such as herbicides or helminthicides impacting other organism groups could also be a factor in bumblebee decline (Lumaret, 1986; Madsen et al., 1990; Colin & Belzunces, 1992; Vandame & Belzunces, 1998; Hayes et al., 2002; Mussen et al., 2004; Simon-Delso et al., 2014).”