humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila.

By Jennifer L. Bandura, E. Beall, M. Bell, Hannah R Silver, M. Botchan, B. Calvi. 2005

39 citations recorded by the source corpus.

Subfields: History

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1. Yang Lim
2. Emily Nielsen-Dandoroff
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Citations in the corpus

• In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “Phenotypic analysis in Drosophila suggested that DONSON plays a role in DNA replication ( 25 ).”
• DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation (2023, background): “…the Drosophila homologue of DONSON, humpty dumpty ( hd ), was also found to be essential for DNA replication, especially in early cleavage divisions of fly embryos, as hd knockout embryos arrested during the first few nuclear cleavage cycles with incomplete chromosome segregation ( 27 , 28 ).”
• Biallelic and De Novo Variants in DONSON Reveal a Clinical Spectrum of Cell Cycle-opathies with Microcephaly, Dwarfism and Skeletal Abnormalities (2019, methodology): “In addition, they also demonstrated that Hd-null flies survived until metamorphosis, and displayed a small brain size, no detectable imaginal discs, and small under-replicated polytene chromosomes, all features highly suggestive of defects in DNA replication and cell-proliferation (Bandura et al., 2”
• DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans (2023, unknown): “However, mutation of the Drosophila orthologue, known as humpty dumpty, produced DNA synthesis defects (38).”
• The expanding genetic and clinical landscape associated with Meier-Gorlin syndrome (2023, background): “While the role of DONSON in DNA replication and cell cycle progression has become clearer [15, 55, 56], the protein itself is somewhat of an enigma.”
• Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome (2017, background): “these results are consistent with arrest prior to or slowed progression through S phase seen withDONSON loss in fly and HeLa cells in prior studies (Bandura et al. 2005; Fuchs et al. 2010).”