Classification of Papillomaviruses (PVs) Based on 189 PV Types and Proposal of Taxonomic Amendments

By H. Bernard, R. Burk, Zigui Chen, Koenraad van Doorslaer, H. zur Hausen, E. de Villiers. Virology, 2010

1,690 citations recorded by the source corpus.

We present an expansion of the classification of the family Papillomaviridae, which now contains 29 genera formed by 189 papillomavirus (PV) types isolated from humans (120 types), non-human mammals, birds and reptiles (64, 3 and 2 types, respectively). To accommodate the number of PV genera exceeding the Greek alphabet, the prefix “dyo” is used, continuing after the Omega-PVs with Dyodelta-PVs. The current set of human PVs are contained within five genera, whereas mammalian, avian and reptile PVs are contained within 20, 3 and 1 genera, respectively. We propose standardizations to the names of a number of animal PVs. As prerequisite for a coherent nomenclature of animal PVs, we propose founding a Reference Center for Animal PVs. We discuss that based on emerging species concepts derived from genome sequences, PV types could be promoted to the taxonomic level of species, but do not recommend implementing this change at the current time.

Subfields: Epidemiology, Genetics, Microbiology

View Paper: https://www.semanticscholar.org/paper/75c13cb3b6ca72e6df9b8f6c3d08df196c2154b0

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Citations in the corpus

The Papillomavirus Episteme: a major update to the papillomavirus sequence database (2016, background): “To be recognized as a novel papillomavirus type, a viral genome has to fulfill a strict set of requirements (for details see (14,15)): (i) The entire viral genome must be cloned; (ii) the L1 sequence cannot share >90% nucleotide sequence identity with its closest neighbour and (iii) the cloned genom”
Human papillomavirus molecular biology and disease association (2015, background): “Human types are divided into five genera based on differences in their DNA sequence, with individual types having a nucleotide sequence (sampled from the L1 gene) that is at least 10%dissimilar from that of other papillomaviruses [10].”
The biology and life-cycle of human papillomaviruses. (2012, background): “The cutaneous Alpha types are also ‘low-risk’, nd include HPV2 and 57, which cause common warts, and HPV3 nd 10, which cause flat warts [1,20].”