Variation in FTO contributes to childhood obesity and severe adult obesity

By C. Dina, D. Meyre, S. Gallina, E. Durand, A. Körner, P. Jacobson, L. Carlsson, W. Kiess, V. Vatin, C. Lecoeur and 17 more. Nature Genetics, 2007

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Overexpression of Fto leads to increased food intake and results in obesity (2010, background): “Genome-wide association studies have revealed that SNPs (including rs9939609, rs17817449, rs3751812, rs1421085 and rs9930506) in intron 1 of FTO are associated with an increased risk of obesit”
Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits (2007, result): “In addition, two other large independent studies also show association of SNPs in FTO with increased BMI [49,50].”
N6-methyladenosine Modulates Messenger RNA Translation Efficiency (2015, positive): “The two mA demethylases (FTO and AlkBH5) have been associated with human body weight (Dina et al., 2007; Frayling et al., 2007; Do et al., 2008) and mouse fertility (Zheng et al.”