Epidemiology of HCC: Consider the Population

By S. Mittal, H. B. EL‐SERAG. Journal of Clinical Gastroenterology, 2013

1,027 citations recorded by the source corpus.

Hepatocellular carcinoma (HCC) is increasing in incidence and has a very high fatality rate. Cirrhosis due to chronic hepatitis B or hepatitis C is the leading risk factor for HCC. Global epidemiology of HCC is determined by prevalence of dominant viral hepatitis and the age it is acquired in the underlying population. Upcoming risk factors include obesity, diabetes and related non-alcoholic fatty liver disease. This review discusses the latest trends of HCC globally and in the United States. It also provides an evidence-based commentary on the risk factors and lists some preventive measures to reduce the incidence of HCC.

Subfields: Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/75a610f7ac201d36ccfd2e05b6fc78f1bc84df3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Jemal
2. R. Siegel
3. F. Bray
4. J. Ferlay
5. Elizabeth E. Ward
6. J. Rowe
7. Idrees Mian
8. Yezaz A. Ghouri

In Hepatology

1. A. Jemal
2. J. Rowe
3. Idrees Mian
4. Elizabeth E. Ward
5. Yezaz A. Ghouri

Citations in the corpus

• Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis (2017, background): “In the US surveillance, epidemiology, and end results (SEER) database program, HCC accounts for 65% of all cases of liver cancers.[7,8] The incidence rate of HCC has increased from 1.”
• Global Cancer in Women: Burden and Trends (2017, background): “Obesity and type II diabetes may also have contributed to the recent increase in the incidence rates in the United States and other parts of the world (154, 166).”
• Global Cancer Incidence and Mortality Rates and Trends—An Update (2015, background): “In the United States, these increases are thought to be attributable to increased prevalence of chronic infectionwithHCVas a result of exposure to contaminated blood or medical equipment and injection drug abuse during the 1960s and 1970s, and possibly contributed to by increases in obesity and type”
• Global cancer statistics, 2012 (2015, background): “Among individuals who are already infected with HBV or HCV, a reduction in the risk of liver cancer has been shown with the use of antiviral treatments.(82,87) However, these treatments may be costly and unfeasible in many low-resource countries.”