Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
By Matteo Ricchi, Maria Rosaria Odoardi, L. Carulli, C. Anzivino, S. Ballestri, A. Pinetti, L. Fantoni, F. Marra, M. Bertolotti, S. Banni and 3 more. Journal of Gastroenterology and Hepatology, 2009
629 citations recorded by the source corpus.
Subfields: Epidemiology, Nutrition and Dietetics, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/759d1497cbae657cce1483fc41bed68cf7792c06
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Citations in the corpus
- Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages (2018, neutral): “…its level in the liver was not significantly altered by the HFD. Palmitic acid can act as an inflammatory signaling molecule, whereas oleic acid is a quantitatively important substrate for esterification and promotes lipid accumulation through modulation of SREBP-1c activity (Ricchi et al., 2009).”
- Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites (2010, background): “Early studies of lipotoxicity demonstrated this in cardiomyocytes,(35) and subsequently, a protective effect of triglyceride droplet formation has been demonstrated in cultured pancreatic islet cells(36) and hepatocytes.(37) However, storage of triglyceride as fat droplets is only a temporizing meas”
- Fatty Acid and Endotoxin Activate Inflammasomes in Mouse Hepatocytes that Release Danger Signals to Stimulate Immune Cells (2011, positive): “, oleic acid) are lipogenic and protect against the apoptotic effects of saturated FAs in cell cultures.(22) PA and LPS together lead to inflammasome and caspase-1 activation.”