NALT- versus PEYER'S-patch-mediated mucosal immunity

By H. Kiyono, S. Fukuyama. Nature reviews. Immunology, 2004

753 citations recorded by the source corpus.

Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue (NALT) organogenesis is different from that of other lymphoid tissues. NALT has an important role in the induction of mucosal immune responses, including the generation of T helper 1 and T helper 2 cells, and IgA-committed B cells. Moreover, intranasal immunization can lead to the induction of antigen-specific protective immunity in both the mucosal and systemic immune compartments. Therefore, a greater understanding of the differences between NALT and other organized lymphoid tissues, such as Peyer's patches, should facilitate the development of nasal vaccines.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/753cba5068f0e97b3f76b9b42be757308aa2f4f6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Czerkinsky
2. J. Holmgren

Citations in the corpus

• Mucosal immunity and vaccines (2005, background): “It is comprised of anatomically defined lymphoid microcompartments such as the Peyer patches, the mesenteric lymph nodes, the appendix and solitary follicles in the intestine, and the tonsils and adenoids at the entrance of the aerodigestive tract, which serve as the principal mucosal inductive site”