New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

By O. Coqueret. Trends in Cell Biology, 2003

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Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle (2006, background): “…pair Cdh1 and UbcH10. p27 ð CycD ^ CycE ^ CycA ^ CycB Þ _ ð p 27 ^ ð CycE ^ CycA Þ ^ CycB ^ CycD Þ ð CycE ^ CycA Þ ^ CycB ^ CycD Þ p27 is active in the absence of the cyclins; when p27 is already present, it blocks the action of CycE or CycA (but not both of them) by sequestration (Coqueret, 2003).”
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms (2009, background): “…Cdk2/cyclin E activation is the initiation of targeted degradation of p27, due to phosphorylation at threonine 187 whereas p27 bound Oncogene to Cdk4-6/cyclin D is stable (Coqueret, 2003). p27 bound to Cdk4-6/cyclin D is released when cyclin D is degraded, and can subsequently bind new complexes.”