New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression: A Prospective Cohort Comparison With Other Phenotypes.

By S. Fereshtehnejad, S. R. Romenets, Julius B. M. Anang, V. Latreille, J. Gagnon, R. Postuma. JAMA Neurology, 2015

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Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, unknown): “More rapid progression of all clinical features was predicted by the presence of REM behavioral disorder, mild cognitive impairment, and orthostatic hypotension in another.(29) To date, PD subtypes have been characterized on the basis of readily apparent and evaluable clinical”
Patient Subtyping via Time-Aware LSTM Networks (2017, background): “05, a signicant group eect is considered for the associated features [15].”
Update of the MDS research criteria for prodromal Parkinson's disease (2019, background): “For example, some evidence suggests that the presence of RBD, orthostatic hypotension, and cognitive deficits is associated with a more malignant PD phenotype, which will likely have a different prodromal state.(66) Similarly, patients with LRRK2 mutations often have prominent prodromal gait deficit”