The behavior and significance of slow-binding enzyme inhibitors.

By J. Morrison, C. Walsh. Advances in Enzymology and Related Subjects, 2006

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Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease (2020, neutral): “where P(t) is the fluorescence signal at time t, P0 is the background signal at time 0, V0, Vs, and k represent, respectively, the initial velocity, the final steady-state velocity and the apparent first-order rate constant for the establishment of the equilibrium between EI and EI*.(42) k2/KI is co”
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. (2013, methodology): “The enzyme inhibition constant (Ki) value for EPZ5676 was determined by fitting inhibition data to the Morrison quadratic equation.(34) Residence times for EPZ-5676 and EPZ004777 were calculated as the reciprocal of the enzymatic-ligand dissociation rate, determined by surface plasmon resonance usin”