Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus

By S. Yamaguchi, H. Isejima, Takuya Matsuo, Ryusuke Okura, K. Yagita, Masaki Kobayashi, H. Okamura. Science, 2003

947 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/743ec69a008f0751e27cb4d3fa6358f636619942

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Takahashi
2. C. Green
3. Evgeny Volkov
4. Jürgen Kurths
5. Aneta Koseska
6. D. Golombek
7. R. Rosenstein
8. U. Albrecht

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. Green
3. C. H. Ko
4. J. Mohawk
5. Ethan D. Buhr
6. Steve A. Kay
7. David K. Welsh
8. D. Golombek

In Plant Science

1. J. Takahashi
2. C. H. Ko
3. C. Green
4. Ethan D. Buhr
5. Steve A. Kay
6. Evgeny Volkov
7. Jürgen Kurths
8. Aneta Koseska

Citations in the corpus

• Coupled oscillators control morning and evening locomotor behaviour of Drosophila (2004, result): “Recent results also show that clocks in different SCN subregions have different phase”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “Glucocorticoid-response elements exist in the regulatory regions of the core clock genes, Bmal1, Cry1, Per1 (Reddy et al. 2007, Yamamoto et al. 2005), and Per2 (So et al. 2009).”
• Molecular components of the mammalian circadian clock. (2006, background): “When intercellular communication via action potentials is lost by blocking voltagegated Na channels with tetrodotoxin (TTX), the circadian oscillations of Per1 and Per2 are greatly reduced and the synchrony of cells within the tissue loses phase coherence (Yamaguchi et al. 2003).”
• Oscillation quenching mechanisms: Amplitude vs. oscillation death (2013, background): “In mammals, for example, a coherent circadian output is a result of synchronization of thousands of diverse neurons in the suprachiasmatic nucleus [21–24].”
• Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, methodology): “Blocking action potentials with TTX for several days allows SCN neurons in slice culture or high density dispersed culture to desynchronize (116, 123).”
• Physiology of circadian entrainment. (2010, background): “It has been proposed that these calbindin cells in the SCN core, although not endogenously rhythmic, might be responsible for cell-to-cell synchronization in the whole nuclei (517).”
• Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, background): “…rhythms, whereas individual neurons in dispersal are not synchronized (Figure 6; Welsh et al., 1995; Liu et al., 1997; Herzog et al., 1998, 2004; Yamaguchi et al., 2003; Aton and Herzog, 2005), implies that the robust rhythmicity of the SCN ensemble is attained by oscillator coupling…”