The complex role of estrogens in inflammation.

By R. Straub. Endocrine reviews, 2007

1,859 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/74356a425d8933c60ab9d3d1762c6f20bbc680af

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Yoav Gilad
2. Carole Ober
3. S. Klein
4. D. Robinson
5. D. Jamieson
6. A. Kourtis
7. J. Read

In Immunology

1. M. Mack
2. S. Klein
3. D. Robinson
4. D. Jamieson
5. A. Kourtis
6. J. Read

In Reproductive Medicine

1. S. Klein
2. D. Robinson
3. D. Jamieson
4. A. Kourtis
5. J. Read

Citations in the corpus

• Gender differences in autoimmune disease. (2014, neutral): “and IL1-b) (Straub, 2007).”
• How sex and age affect immune responses, susceptibility to infections, and response to vaccination (2015, background): “Partially controversial results were reported regarding hormonal effects on the cytokine secretion pattern of T lymphocytes (reviewed in Bouman et al., 2005; Straub, 2007; Gonzalez et al., 2010; Oertelt-Prigione, 2012).”
• Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis (2012, background): “Estradiol can enhance both cell-mediated and humoral immune responses (Straub, 2007).”
• Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings (2009, background): “In general, women show a heightened inflammatory response compared with men.(394) Although beneficial for wound healing and response to infection, this more robust inflammatory response places women at significantly greater risk for a variety of painful inflammatory autoimmune conditions, including ”
• Sex-specific genetic architecture of human disease (2008, background): “Interestingly, immune responses might be modulated by sex hormone”
• Inflammation and Pregnancy (2006, background): “Estrogen appears to play a critical role in some immune response and immune-mediated diseases.(11) Based on a distinctive profile of cytokine production, estrogens have modulatory effects on immune function, inhibiting Th1 proinflammatory cytokines, such as IL-12, TNF-a, and IFN-g stimulating Th2 an”
• Sex-based differences in susceptibility to SARS-CoV infection (2017, background): “Although testosterone suppresses innate immune responses, hormones such as estrogens have disparate functions, with an immune-suppressive effect at high concentrations and immunostimulatory activity at low concentrations (23, 24, 33, 34).”
• Pregnancy and infection. (2014, positive): “51,52 In general, low estradiol concentrations promote CD4+ type 1 helper T-cell (Th1) responses and cell-mediated immunity, and high estradiol concentrations augment CD4+ type 2 helper T-cell (Th2) responses and humoral immunity.”