Heart Physiology: From Cell to Circulation

By L. Opie. 2003

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Cardiac Metabolism and Its Interactions with Contraction, Growth, and Survival of the Cardiomyocte (2013, methodology): “Targeting Substrate Preference The shift of substrate preference to glucose in pathological hypertrophy was considered adaptive based on the theoretical higher oxygen efficiency of ATP synthesis from glucose.(121) Therefore, various metabolic therapies focusing on the promotion of glucose oxidation ”
Cardiac Metabolism in Heart Failure - Implications beyond ATP production (2013, unknown): “The Krebs Cycle and Anaplerosis Acetyl-CoA, the common end product of glucose and FA oxidation, enters the citric acid cycle (also known as tricarboxylic acid cycle or Krebs cycle) to generate GTP (or ATP), CO 2 , and reducing equivalents NADH 2 .(2) Because Krebs cycle intermediates can be used for”
Mechanisms of sepsis-induced cardiac dysfunction (2007, background): “However, prolonged and excess stimulation can lead to myocardial damage by calcium overload and consequent cell necrosis (143).”