Clinical blockade of PD1 and LAG3 — potential mechanisms of action

By L. Nguyen, P. Ohashi. Nature reviews. Immunology, 2014

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Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “Traditionally, it was believed that immunotherapyactivated CD8+ T cells induce tumor cell death mainly through the perforin-granzyme pathway and the Fas-Fas ligand (FASL) pathway.(26,27) However, many studies have surprisingly revealed that CD8+ T cells can suppress tumors by inducing ferroptosis an”
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer (2017, unknown): “47) have begun.”
Next generation of immune checkpoint therapy in cancer: new developments and challenges (2018, background): “Targeting LAG-3 with antagonistic mAbs interferes with the LAG-3 interaction between MCH II molecules expressed by tumor and/or immune cells, promoting tumor cell apoptosis [19].”