Cross talk of the interferon‐α/β signalling complex with gp130 for effective interleukin‐6 signalling

By Y. Mitani, A. Takaoka, Sun Hwa Kim, Y. Kato, T. Yokochi, N. Tanaka, Tadatsugu Taniguchi. 2001

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Interferon signalling network in innate defence (2006, background): “, 1995) similarly to virusinduced IFNs, several studies by our group provided a mechanistic insight into this unique system (Takaoka et al., 2000; Hata et al., 2001; Mitani et al., 2001; Taniguchi and Takaoka, 2001).”
Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1 (2005, background): “Taniguchi and coworkers (16) have shown that signaling by IL-6 and IFN- receptors is attenuated in cells deficient in the type I IFNAR because the IFNR is needed to provide a docking site for efficient STAT dimerization, and they suggested that similar cross-talk may affect activation of STAT 4 by I”