NF-κB in neuronal plasticity and neurodegenerative disorders

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To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis (2003, background): “These results agree with the elevated levels of NF-kB-dependent antiapoptotic proteins observed in many human tumors, including Bfl-1/ A1, c-IAP2, Bcl-xL and Bcl-2.”
The neuropathogenesis of AIDS (2005, background): “results in alterations in gene expression that are crucial for the response of neurons to insult”
Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-κB p50-Deficient Mice (2008, background): “…major and opposed functions in neurons, because they can both promote and protect against cell death (Grilli et al., 1996; Denk et al., 2000; Mattson and Camandola, 2001; Mattson and Meffert, 2006), substantiating the hypothesis that they could play roles in the control of the net rate of…”
Mechanisms of neurodegeneration and regeneration in alcoholism. (2009, background): “In the central nervous system, NF-κB proteins are ubiquitously expressed in neurons and glia (Kaltschmidt et al., 1993; Mattson and Camandola, 2001) where, in addition to regulating physiological processes, they participate in pathological events (O’Neill and Kaltschmidt, 1997; Grilli and Memo, 1999”